The SNAI1 Antibody from MyBioSource.com is a Mouse Monoclonal antibody to SNA, SNAI1, Snail, and SNAIL1. This antibody recognizes Human antigen. The SNAI1 Antibody has been validated for the following applications: ELISA, and Western Blot.
Description
Background: Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells. Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines. In addition, Snail blocks the cell cycle and confers resistance to cell death. Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function.Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney